Viagra Description:
Viagra (Sildenafil citrate) is a drug
used to treat erectile dysfunction (impotence) in males and pulmonary
arterial hypertension (PAH).
Background:
The pharmaceutical company, Pfizer, originally developed Viagra. In
1006, the FDA approved Viagra as the first drug patented for use of
erectile dysfunction in the United States. They are blue,
diamond-shaped pills with "Pfizer" marked on one side and "VGR XX." The
XX is the dosage, which is either 25,50, or 100 mgs. Viagra is also
sold under the brand name Revatio and generically under various other
names. It is also widely availabe by many research companies and
underground labs.
Action:
Viagra treats erectile dys function and works by relaxing muscles and
increases blood flow to particular areas of the body (in this case, the
penis, specifically). Its effects last up to four hours. The most
common side effects of Viagra are headache, facial flushing, and upset
stomach. Rarely, blurred vision, or sensitivity to light may briefly
occur.
As well as treating impotence, Sildenafil Citrate can also be effective
in treating Pulmonary Arterial Hypertension (PAH). Similarly to how it
acts to relax muscles of the penis, it relaxes arterial walls;
therefore, reducing resistance and pressure in the arteries.
Sildenafil Citrate is solely active in relaxing muscles and increasing
blood flow to the heart, lungs and penis due to PDE-5, yet vasodilation
is not increased in other parts of the body.
Technical Data:
In studies where Viagra was administered to over 3700 patients, 19-87
years old in world wide clinical trials. More than 550 patients
received treatment post 1 year. 2.5% of the Viagra subjects and 2.3% of
the placebo subjects reported adverse effects, which were all
considered mild. These reported side effects included abnormal or
blurred vision and increased sensitivity to light (1). All other
negative reactions reported, including URI, flu symptoms, back pain and
arthralgia, occurred at a rate of less than 2% and equally common in
the placebo and Viagra administered groups (1). Effects worsened and
were reported more frequently as dosages increased (1).
Other studies measured duration of sexually stimulated erection using a
Rigiscan device. Duration of rigidity was increased by 60% with Viagra
use (2).
In 16 separate 4-24 week trials of men (over 18 years old) who suffered
from impotence for longer than 6 months, dosages between 10-200 mgs
were administered (3). Significant improvements in erectile function,
including frequency of penetration as well as erection duration post
penetration, were reported with Sildenfil treatment compared to the
placebo group (4). Erections were improved in 72% of the Viagra group
verses 18% of the placebo group (5). In all cases effects were
dependant upon dosage and improvement was the greatest when dosage
exceeded 100 mgs (6). Responses were decreased by 40-60% in patients
suffering from diabetes and prostatectomy, respectively (7)(8).
Withdrawal rates were less than 5% related to negative side effects and
limited response rates (9).
Sildenafil citrate is the chemical name of active ingredient in Viagra.
Viagra is a registered trademark of Pfizer Inc. in the United States
and/or other countries.
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Viagra Information
Sildenafil Citrate
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